Approach to the infertile couple
Infertility has become a growing condition.
Infertility is defined as the inability to achieve a clinical pregnancy. after 12 months of regular unprotected sexual relations. In women over 35 years of age, the study should be started after 6 months due to the natural decrease in ovarian reserve.
In Mexico, the Global Fertility Rate has decreased to 1.9 children per woman (INEGI 2021), reflecting demographic changes and an increase in cases of infertility, both female and male.
What are the most frequent causes in the treatment of infertile couples?
Infertility can be due to female, male or mixed factors:
Female factors (40–50%)
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Ovulatory disorders, including Polycystic Ovary Syndrome (PCOS).
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Tubal problems secondary to infections or endometriosis.
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Alterations in the uterus or cervix, such as fibroids or malformations.
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Endocrine disorders: insulin resistance, thyroid dysfunction, hyperprolactinemia.
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Low reservation ovarian, evaluated by AMH, FSH and antral follicle count.
Male factors (30–40%)
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Alterations in the concentration, mobility or morphology of sperm.
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Surgical history, exposure to heat, toxins or infections.
Spermatobioscopy is the initial test to identify alterations in semen.
Idiopathic infertility (10–20%)
It occurs when a clear cause cannot be identified after a complete study.
What is the importance of time in fertility?
Time is a critical factor in the approach to the infertile couple, since the chances of pregnancy decrease as the months of unsuccessful search pass.
In healthy couples under 35 years of age:
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20% achieve the pregnancy in one month
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70% in 6 months
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90% in one year
When there is some factor of infertility, the probabilities drop to approximately 48% in one year, which is why a timely evaluation is recommended.
When to start the infertility study?
It is recommended to start the approach when:
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before the age of 35: after 12 months without achieving pregnancy.
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after the age of 35: after 6 months.
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Immediately if exists:
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Endometriosis
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Menstrual disorders
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Uterine or tubal disease
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Thyroid disorders
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Suspicion of male factor
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An early diagnosis reduces the emotional burden and allows the most appropriate treatment to begin.
A complete clinical evaluation is the essential first step.
The clinical history is a fundamental tool in the approach to the infertile couple. Must include:
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Weight, height, BMI and visible hormonal changes (acne, hirsutism, galactorrhea).
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Menstrual rhythm, surgical history and previous illnesses.
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Exposure to toxic substances or medications that affect fertility.
A good initial assessment avoids unnecessary studies and guides the medical team towards the most probable cause.
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